CRISPR/Cas9: at the cutting edge of hepatology.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28487442.
- Also identified by DOI 10.1136/gutjnl-2016-313565 and PMC identifier 5878048.
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Abstract
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome engineering has revolutionised biomedical science and we are standing on the cusp of medical transformation. The therapeutic potential of this technology is tremendous, however, its translation to the clinic will be challenging. In this article, we review recent progress using this genome editing technology and explore its potential uses in studying and treating diseases of the liver. We discuss the development of new research tools and animal models as well as potential clinical applications, strategies and challenges.
Medical subject headings
- CRISPR-Cas Systems
- Gene Editing