Osteocyte dysfunction and renal osteodystrophy: not just calcium and phosphorus anymore.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 28501301.
- Also identified by DOI 10.1016/j.kint.2017.02.026.
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Abstract
In an important new cross-sectional analysis in this issue, Graciolli and colleagues present bone data from 148 adult patients across the spectrum of chronic kidney disease that confirm that disrupted osteocyte function and abnormal bone histology characterize all stages of chronic kidney disease and suggest that osteocytic Wnt signaling and osteocyte maturation may play a role in the pathogenesis of renal osteodystrophy. These concepts may alter how the skeletal, cardiovascular, and infectious complications of chronic kidney disease are managed.
Medical subject headings
- Calcium
- Chronic Kidney Disease-Mineral and Bone Disorder