Potential relevance of shear stress for slit diaphragm and podocyte function.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28501303.
- Also identified by DOI 10.1016/j.kint.2017.02.032.
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Abstract
Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot processes, preventing widening of the slit.
Medical subject headings
- Glomerular Basement Membrane
- Glomerular Filtration Rate
- Mechanotransduction, Cellular
- Podocytes