Aging and the immune response to organ transplantation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28504651.
- Also identified by DOI 10.1172/JCI90601 and PMC identifier 5490761.
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Abstract
An increasing number of older people receive organ transplants for various end-stage conditions. Although organ transplantation is an effective therapy for older patients (i.e., older than 65 years of age), such as in end-stage renal disease, this therapy has not been optimized for older patients because of our lack of understanding of the effect of aging and the immune response to organ transplantation. Here, we provide an overview of the impact of aging on both the allograft and the recipient and its effect on the immune response to organ transplantation. We describe what has been determined to date, discuss existing gaps in our knowledge, and make suggestions on necessary future studies to optimize organ transplantation for older people.
Medical subject headings
- Aging
- Kidney Failure, Chronic
- Kidney Transplantation
- Transplantation Immunology