Substantial Impairment of Voriconazole Clearance by High-Dose Meropenem in a Patient With Renal Failure.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 28505263.
- Also identified by DOI 10.1093/cid/cix443.
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Abstract
A critically ill patient with multiple postoperative infections repeatedly required profound voriconazole dose reductions whenever high-dose meropenem was added. Subsequent in vitro assessment confirmed inhibition of cytochrome P450 (CYP) 2C19 and CYP3A4 by meropenem, suggesting that during meropenem treatment, narrow therapeutic index drugs metabolized by these CYPs require close monitoring.
Medical subject headings
- Cytochrome P-450 CYP2C19 Inhibitors
- Cytochrome P-450 CYP3A Inhibitors
- Thienamycins
- Voriconazole