Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28515434.
- Also identified by DOI 10.1038/nrn.2017.48 and PMC identifier 5759779.
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Abstract
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.
Medical subject headings
- Alzheimer Disease
- Brain
- Cerebrovascular Circulation
- Cerebrovascular Disorders
- Neurovascular Coupling