¹⁸F-FDG PET Response After Induction Chemotherapy Can Predict Who Will Benefit from Subsequent Esophagectomy After Chemoradiotherapy for Esophageal Adenocarcinoma.

Abstract

This study aimed to determine whether ¹⁸F-FDG PET response after induction chemotherapy before concurrent chemoradiotherapy can identify patients with esophageal adenocarcinoma who may benefit from subsequent esophagectomy. <b>Methods:</b> We identified and analyzed 220 patients with esophageal adenocarcinoma who had received induction chemotherapy before chemoradiotherapy, with or without surgery, with curative intent; all underwent ¹⁸F-FDG PET scanning before and after induction chemotherapy. ¹⁸F-FDG PET responders were defined as patients who achieved complete response (CR) after induction chemotherapy (maximum SUV ≤ 3.0). The predictive value of ¹⁸F-FDG PET response for patient outcomes was evaluated. <b>Results:</b> Overall, 86 patients had bimodality therapy (BMT; induction chemotherapy + chemoradiotherapy) and 134 had trimodality therapy (TMT; induction chemotherapy + chemoradiotherapy with surgery). Forty-eight patients (21.8%) achieved an ¹⁸F-FDG PET CR after induction chemotherapy. ¹⁸F-FDG PET CR was found to correlate with overall survival (OS) and progression-free survival (PFS) in BMT patients. For TMT patients, ¹⁸F-FDG PET CR predicted pathologic response (<i>P</i> = 0.003) but not survival. Among ¹⁸F-FDG PET nonresponders, TMT patients had significantly better survival than did BMT patients (<i>P</i> < 0.001). However, among ¹⁸F-FDG PET responders, BMT patients had OS (<i>P</i> = 0.201) and PFS (<i>P</i> = 0.269) similar to that of TMT patients. After propensity score-matched analysis, ¹⁸F-FDG PET responders treated with BMT versus TMT still had comparable OS and PFS, but TMT was associated with better locoregional control. <b>Conclusion:</b>¹⁸F-FDG PET response to induction chemotherapy could be a useful imaging biomarker to identify patients with esophageal adenocarcinoma who could benefit from subsequent esophagectomy after chemoradiotherapy. Compared with BMT, TMT can significantly improve survival in ¹⁸F-FDG PET nonresponders. However, outcomes for ¹⁸F-FDG PET responders were similar after either treatment (BMT or TMT). Prospective validation of these findings is warranted.