Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28525751.
- Also identified by DOI 10.1016/j.cell.2017.04.022 and PMC identifier 5532494.
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Abstract
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.
Medical subject headings
- Cell Nucleus
- Chromatin