Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28530824.
- Also identified by DOI 10.1021/acs.nanolett.7b00189.
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Abstract
We atomistically compute the change in free energy upon binding of the globular domain of the complement protein C1q to carbon nanotubes (CNTs) and graphene in solution. Our modeling results imply that C1q is able to disaggregate and disperse bundles of large diameter multiwalled CNTs but not those of thin single-walled CNTs, and we validate this prediction with experimental observations. The results support the view of a strong binding with potential implications for the understanding of the immune response and biomedical applications of graphitic nanomaterials.
Medical subject headings
- Complement C1q
- Graphite
- Nanotubes, Carbon