Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity.
Level V
Where this comes from
- Record sourced from PubMed, PMID 28532654.
- Also identified by DOI 10.1016/j.jaci.2017.05.005 and PMC identifier 5632575.
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Abstract
This is the first study determining the three-dimensional structure of Phl p 5a which reveals a novel mechanism for high allergenic activity based on flexibly connected IgE-reactive domains which cross-link effector cell-bound IgE more efficiently than isolated rigid globular proteins. These findings may also form a basis for specific immunotherapy strategies.
Medical subject headings
- Allergens
- Epitopes
- Immunoglobulin E
- Plant Proteins