Antigen-specific CD8<sup>+</sup> T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28537251.
- Also identified by DOI 10.1038/ncomms15402 and PMC identifier 5458103.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8<sup>+</sup> T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1β maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity.
Medical subject headings
- Graft vs Host Disease
- Inflammasomes
- NLR Family, Pyrin Domain-Containing 3 Protein
- Neoplasms
- Perforin
- T-Lymphocytes, Cytotoxic