The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28541488.
- Also identified by DOI 10.1093/rheumatology/kex186.
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Abstract
In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.
Medical subject headings
- Inflammatory Bowel Diseases
- Interleukin-12
- Interleukin-23
- Psoriasis
- T-Lymphocytes