Genetically engineered mouse models of melanoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28543694.
- Also identified by DOI 10.1002/cncr.30684 and PMC identifier 5445933.
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Abstract
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103. © 2017 American Cancer Society.
Medical subject headings
- Disease Models, Animal
- Melanoma
- Mice
- Skin Neoplasms