Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28552347.
- Also identified by DOI 10.1016/j.cell.2017.05.002 and PMC identifier 5504703.
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Abstract
The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of T<sub>regs</sub> and HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs.
Medical subject headings
- Hair Follicle
- Stem Cells
- T-Lymphocytes, Regulatory