Engineered clearing agents for the selective depletion of antigen-specific antibodies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28561044.
- Also identified by DOI 10.1038/ncomms15314 and PMC identifier 5460014.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.
Medical subject headings
- Autoimmune Diseases
- Diagnostic Imaging
- Drug Design
- Histocompatibility Antigens Class I
- Receptors, Fc
- Recombinant Fusion Proteins