A new therapeutic target for myelofibrosis is cause for Gli.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28566426.
- Also identified by DOI 10.1126/scitranslmed.aan4297 and PMC identifier 5546312.
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Abstract
Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor.
Medical subject headings
- Mesenchymal Stem Cells
- Primary Myelofibrosis