Senescence in Health and Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28575665.
- Also identified by DOI 10.1016/j.cell.2017.05.015 and PMC identifier 5643029.
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Abstract
Many cellular stresses activate senescence, a persistent hyporeplicative state characterized in part by expression of the p16<sup>INK4a</sup> cell-cycle inhibitor. Senescent cell production occurs throughout life and plays beneficial roles in a variety of physiological and pathological processes including embryogenesis, wound healing, host immunity, and tumor suppression. Meanwhile, the steady accumulation of senescent cells with age also has adverse consequences. These non-proliferating cells occupy key cellular niches and elaborate pro-inflammatory cytokines, contributing to aging-related diseases and morbidity. This model suggests that the abundance of senescent cells in vivo predicts "molecular," as opposed to chronologic, age and that senescent cell clearance may mitigate aging-associated pathology.
Medical subject headings
- Aging
- Cell Cycle
- Cellular Senescence