Aldehydes Pose a Threat to BRCA2 Mutation Carriers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28575676.
- Also identified by DOI 10.1016/j.cell.2017.05.021.
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Abstract
Humans with inherited heterozygous BRCA2 mutations have an increased risk of developing cancer; however, what triggers carcinogenesis in these individuals is unclear. Tan et al. find that environmental and metabolic aldehydes pose a threat to these individuals by promoting degradation of wild-type BRCA2 protein, thereby predisposing them to genomic instability and perhaps to cancer.
Medical subject headings
- Aldehydes
- Mutation