Gli-fully Halting the Progression of Fibrosis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28575684.
- Also identified by DOI 10.1016/j.stem.2017.05.003.
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Abstract
Activating triggers, selective markers, and the residual regenerative potential of scar-forming myofibroblasts are largely determined by their origin. In this issue of Cell Stem Cell, Schneider et al. report that bone marrow myofibroblasts derive from Gli1<sup>+</sup> mesenchymal stromal cells and that a Gli inhibitor targets them for elimination in mice and humans, ameliorating fibrosis.
Medical subject headings
- Mesenchymal Stem Cells
- Primary Myelofibrosis