Mitotic Bookmarking: Maintaining the Stem Cell Identity during Mitosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28575687.
- Also identified by DOI 10.1016/j.stem.2017.05.002.
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Abstract
In Cell Reports, Liu et al. (2017) investigate mechanisms for how pluripotent stem cells maintain their identity during cell division. They show that the histone mark H3K27ac and pluripotency transcription factors remain associated with mitotic chromatin in ESCs and during iPSC reprogramming, demonstrating the importance of mitotic bookmarking in pluripotency.
Medical subject headings
- Histone Code
- Pluripotent Stem Cells