HUGIn: Hi-C Unifying Genomic Interrogator.
basic_science · Level V
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- Record sourced from PubMed, PMID 28582503.
- Also identified by DOI 10.1093/bioinformatics/btx359 and PMC identifier 5860315.
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Abstract
High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability. We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTL results and functional genomics data. HUGIn is available at http://yunliweb.its.unc.edu/HUGIn. yunli@med.unc.edu or hum@ccf.org. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Chromatin
- Genome-Wide Association Study
- Genomics
- Quantitative Trait Loci
- Regulatory Sequences, Nucleic Acid
- Software