WASH maintains NKp46<sup>+</sup> ILC3 cells by promoting AHR expression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28589939.
- Also identified by DOI 10.1038/ncomms15685 and PMC identifier 5467242.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Innate lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How these ILC lineages develop and are maintained is not clear. Here we show that WASH is highly expressed in the nucleus of group 3 ILCs (ILC3s). WASH deletion impairs the cell pool of NKp46<sup>+</sup> ILC3s. In NKp46<sup>+</sup> ILC3s, WASH recruits Arid1a to the Ahr promoter thus activating AHR expression. WASH deletion in ILC3s decreases the number of NKp46<sup>+</sup> ILC3s. Moreover, Arid1a deletion impedes AHR expression and impairs the maintenance of NKp46<sup>+</sup> ILC3s. Therefore, WASH-mediated AHR expression has a critical function in the maintenance of NKp46<sup>+</sup> ILC3s.
Medical subject headings
- Immunity, Innate
- Inflammation
- Lymphocytes
- Microfilament Proteins
- Natural Cytotoxicity Triggering Receptor 1
- Nuclear Proteins
- Transcription Factors