Type I Interferons Interfere with Liver Glucose Metabolism.
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- Record sourced from PubMed, PMID 28591628.
- Also identified by DOI 10.1016/j.cmet.2017.05.009.
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Abstract
The specific immunological components linking metabolic stresses to liver inflammation and systemic metabolic pathologies in obesity are not entirely known. A recent study (Ghazarian et al., 2017) reveals that obesity-induced type I interferon signaling drives the accumulation and activation of intrahepatic CD8+ T cells, leading to systemic metabolic deterioration.