Rheumatoid arthritis: Forward and reverse inheritance - the yin and the yang.

Nelson, J Lee; Lambert, Nathalie C · Nat Rev Rheumatol · 2017

editorial · Level V

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Abstract

The theory of Mendelian inheritance states that half our genes are maternal and half are paternal. This view is incomplete, as maternal–fetal exchange creates a legacy of non-native cells within an individual that can affect their health for better or worse, including contributing to their risk of developing autoimmune disease.

Medical subject headings