Synthesis of imidazolium-containing mono-methacrylates as polymerizable antibacterial agents for acrylic bone cements.
basic_science · Level V
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- Record sourced from PubMed, PMID 28601760.
- Also identified by DOI 10.1016/j.jmbbm.2017.06.003.
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Abstract
With the aim to prepare antibacterial acrylic bone cements, a series of imidazolium-containg mono-methacrylates with N-alkyl chain length varied from 10 to 18 (MEIM-x) were synthesized as polymerizable antibacterial agents through a two-step reaction. The structures of the monomers were confirmed by <sup>1</sup>H NMR. Methyl methacrylate in the liquid compoent of cements was partially replaced by MEIM-x to prepare bone cements with 5wt% of MEIM-x. Properties of prepared cements like antibacterial activity, doughing time, curing parameters including maximum temperature (T<sub>max</sub>) and setting time (t<sub>set</sub>), flexual strength (FS) and modulus (FM), compressive strength (CS) and fluid uptake (FU) in Ringer's solution were investigated. Acrylic bone cement without any MEIM-x was used as control. Compared with the control cement, MEIM-x-containing cements had shorter doughing time, lower T<sub>max</sub>, same or longer t<sub>set</sub>, and higher FU. Though MEIM-x could endow cements with strong antibacterial activity, it could reduce mechanical properties of bone cements. Therefore, further study should be taken to optimize the content of MEIM-x in cement which could supply sufficient antibacterial activity and maintain mechanical performance.
Medical subject headings
- Anti-Bacterial Agents
- Bone Cements
- Materials Testing
- Methacrylates