Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28621492.
- Also identified by DOI 10.1002/jbmr.3199 and PMC identifier 5585011.
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Abstract
Tendons and ligaments provide connections between muscle and bone or bone and bone to enable locomotion. Damage to tendons and ligaments caused by acute or chronic injury or associated with aging and arthritis is a prevalent cause of disability. Improvements in approaches for the treatment of these conditions depend on a better understanding of tendon and ligament development, cell biology, and pathophysiology. This review focuses on recent advances in the discovery of transcription factors that control ligament and tendon cell differentiation, how cell and extracellular matrix homeostasis are altered in disease, and how this new insight can lead to novel therapeutic approaches. © 2017 American Society for Bone and Mineral Research.
Medical subject headings
- Aging
- Arthritis
- Ligaments
- Tendon Injuries
- Tendons