SnapShot: Phosphoregulation of Mitosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28622516.
- Also identified by DOI 10.1016/j.cell.2017.06.003.
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Abstract
During mitosis, a cell divides its duplicated genome into two identical daughter cells. This process must occur without errors to prevent proliferative diseases (e.g., cancer). A key mechanism controlling mitosis is the precise timing of more than 32,000 phosphorylation and dephosphorylation events by a network of kinases and counterbalancing phosphatases. The identity, magnitude, and temporal regulation of these events have emerged recently, largely from advances in mass spectrometry. Here, we show phosphoevents currently believed to be key regulators of mitosis. For an animated version of this SnapShot, please see http://www.cell.com/cell/enhanced/odonoghue2.
Medical subject headings
- Mitosis
- Protein Kinases