A randomized, placebo-controlled, double-blinded, crossover trial of pioglitazone for severe asthma.

Kaler, Maryann; Barochia, Amisha V; Weir, Nargues A; Cuento, Rosemarie A; Stylianou, Mario; Roth, Mark J; Filie, Armando C; Vaughey, Ellen C et al. · J Allergy Clin Immunol · 2017

rct · Level II

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Abstract

The PPAR-γ agonist, pioglitazone, was associated with significant side effects and did not improve the primary outcome measure of the Juniper Asthma Quality of Life Questionnaire (AQLQ) score in severe asthmatics. We conclude that no further studies should be performed with pioglitazone for severe asthma.

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