T cells from patients with Parkinson's disease recognize α-synuclein peptides.
basic_science · Level V
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- Record sourced from PubMed, PMID 28636593.
- Also identified by DOI 10.1038/nature22815 and PMC identifier PMC5510615.
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Abstract
Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.