Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis.

Abstract

Knee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorphism in ADAM12 gene and risk of knee OA, we performed a meta-analysis based on six related studies, including a total of 2185 cases and 3716 controls. A comprehensive search was performed to identify related studies up to April 14, 2017. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Different genetic models were used to assess the pooled and stratified data. Overall, no significant association was found in all genetic models (C vs. G, OR = 0.983, 95% CI = 0.910-1.061; CC vs. GG, OR = 1.033, 95% CI = 0.851-1.255; CG vs. GG, OR = 1.030, 95% CI = 0.877-1.209; CC/CG vs. GG, OR = 1.031, 95% CI = 0.886-1.201; CC vs. CG/GG, OR = 1.017, 95% CI = 0.868-1.190). When stratified by ethnicity, no significant association was found. This meta-analysis suggested that the rs3740199 polymorphism does not contribute to the development of knee OA. Additional well-designed large studies are required to confirm these findings in different populations.