β<sub>2</sub>-adrenergic receptors in inflammation and vascular complications of diabetes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28646990.
- Also identified by DOI 10.1016/j.kint.2017.03.024.
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Abstract
The cross talk between the immune and nervous systems is critical not only for maintaining normal homeostasis but also for the progression of a variety of inflammatory diseases. Macrophage activation and β<sub>2</sub>-adrenergic receptors are known to play important roles in facilitating this communication between these 2 systems. Using an integrated in vitro and in vivo study, Noh et al. reveal that β<sub>2</sub>-adrenergic receptor agonists exhibit protective effects against the vascular complications of diabetes. The protective effects of β<sub>2</sub>-adrenergic receptor agonists seem to be dependent on a β-arrestin2/inhibitor of kappa B/nuclear factor-κB signaling pathway.
Medical subject headings
- Inflammation
- Signal Transduction