Gastric bypass surgery stimulates the dormant gut-brain axis in obesity.

Caligiuri, Stephanie P B; Kenny, Paul J · Kidney Int · 2017

Level V

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Abstract

To truly reduce the rates of chronic kidney disease, a root cause of kidney damage, obesity, must be targeted. Weight loss is often unsustainable because imbalances in satiety regulators are frequently not addressed to ensure maintenance of weight loss. In a recent study, gastric bypass surgery rebalanced satiety signals through resensitization of the gut-brain axis in obesity. This research may lead to noninvasive strategies to reduce obesity and obesity-related kidney disease.

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