Disease- or Storage-Associated Structural Modifications Are Unlikely to Explain HDL Pro-inflammatory Effects on Macrophages.

van der Vorst, Emiel P C; Theodorou, Kosta; Biessen, Erik A L; Donners, Marjo M P C · Cell Metab · 2017

editorial · Level V

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Abstract

Van der Vorst et al. underscore the relevance of HDL quality control, considering HDL source and processing, but argue that disease- or storage-associated structural modifications of HDL cannot explain the observed pro-inflammatory effects on macrophages. Discrepancies between reported effects of HDL in macrophages are probably related to methodological differences.

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