Prevalence of sexual dimorphism in mammalian phenotypic traits.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28650954.
- Also identified by DOI 10.1038/ncomms15475 and PMC identifier 5490203.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
Medical subject headings
- Mammals
- Quantitative Trait, Heritable
- Sex Characteristics