Hyperthermia effect and antibacterial efficacy of Fe<sup>3+</sup> /Co<sup>2+</sup> co-substitutions in β-Ca<sub>3</sub> (PO<sub>4</sub> )<sub>2</sub> for bone cancer and defect therapy.
basic_science · Level V
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- Also identified by DOI 10.1002/jbm.b.33921.
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Abstract
The combined effect of cobalt and iron substitutions in β-Ca<sub>3</sub> (PO<sub>4</sub> )<sub>2</sub> as a potent material for application in hyperthermia and as a bone substitute is presented. Structural analysis reveals the preferential accommodation of Co<sup>2+</sup> and Fe<sup>3+</sup> at the Ca<sup>2+</sup> (5) sites of β-Ca<sub>3</sub> (PO<sub>4</sub> )<sub>2</sub> until the limit of ∼10 mol % and, thereafter, prefer Ca<sup>2+</sup> (4) lattice sites. Occupancy of both the Co<sup>2+</sup> and Fe<sup>3+</sup> ions induces a significant contraction of the β-Ca<sub>3</sub> (PO<sub>4</sub> )<sub>2</sub> unit cell. The Co<sup>2+</sup> /Fe<sup>3+</sup> co-substitutions in β-Ca<sub>3</sub> (PO<sub>4</sub> )<sub>2</sub> display magnetic characteristics that enhances hyperthermia effect. In addition, the presence of Co<sup>2+</sup> in β-Ca<sub>3</sub> (PO<sub>4</sub> )<sub>2</sub> enunciates pronounced antibacterial efficacy against tested microorganisms. Nevertheless, the enhanced level of Co<sup>2+</sup> in β-Ca<sub>3</sub> (PO<sub>4</sub> )<sub>2</sub> results to induce significant toxicity. The biocompatibility of the synthesized thermoseeds is verified from the hemolytic tests and cytotoxicity test performed on human sarcoma cell line MG-63. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1317-1328, 2018.
Medical subject headings
- Anti-Bacterial Agents
- Bone Neoplasms
- Bone and Bones
- Calcium Phosphates
- Cobalt
- Hyperthermia, Induced
- Iron
- Osteosarcoma