Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28663145.
- Also identified by DOI 10.1016/j.ebiom.2017.06.014 and PMC identifier 5552106.
- Licence recorded as CC BY-NC-ND.
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Abstract
Type 1 diabetes (T1D) has been associated with both genetic and environmental factors. Increasing incidence of T1D worldwide is prompting researchers to adopt different approaches to explain the biology of T1D, beyond the presence and activity of autoreactive lymphocytes. In this review, we propose inflammatory pathways as triggers for T1D. Within the scope of those inflammatory pathways and in understanding the pathogenesis of disease, we suggest that viruses, in particular Coxsackieviruses, act by causing a type 1 interferonopathy within the pancreas and the microenvironment of the islet. As such, this connection and common thread represents an exciting platform for the development of new diagnostic, treatment and/or prevention options.
Medical subject headings
- Coxsackievirus Infections
- Diabetes Mellitus, Type 1
- Interferons
- Pancreatic Diseases