RAS Proteins and Their Regulators in Human Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28666118.
- Also identified by DOI 10.1016/j.cell.2017.06.009 and PMC identifier 5555610.
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Abstract
RAS proteins are binary switches, cycling between ON and OFF states during signal transduction. These switches are normally tightly controlled, but in RAS-related diseases, such as cancer, RASopathies, and many psychiatric disorders, mutations in the RAS genes or their regulators render RAS proteins persistently active. The structural basis of the switch and many of the pathways that RAS controls are well known, but the precise mechanisms by which RAS proteins function are less clear. All RAS biology occurs in membranes: a precise understanding of RAS' interaction with membranes is essential to understand RAS action and to intervene in RAS-driven diseases.
Medical subject headings
- ras Proteins