Superoxide Dismutase-Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28671302.
- Also identified by DOI 10.1002/adhm.201700500 and PMC identifier 5591629.
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Abstract
A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated antioxidant enzyme SOD. In vivo studies in the rat demonstrate that administration of SOD-encapsulated porous polymersomes can prevent neuropathic pain after nerve root compression more effectively than treatment with free antioxidant enzyme alone.
Medical subject headings
- Antioxidants
- Neuralgia
- Polymers
- Superoxide Dismutase