Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada.
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- Record sourced from PubMed, PMID 28678874.
- Also identified by DOI 10.1371/journal.pone.0180347 and PMC identifier 5498056.
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Abstract
We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins.
Medical subject headings
- Escherichia coli
- Escherichia coli Proteins
- Ethanolaminephosphotransferase
- Plasmids