A cell-based mechanical model of coronary artery tunica media.
biomechanical · Level V
Where this comes from
- Record sourced from PubMed, PMID 28679664.
- Also identified by DOI 10.1098/rsif.2017.0028 and PMC identifier 5550961.
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Abstract
A three-dimensional cell-based mechanical model of coronary artery tunica media is proposed. The model is composed of spherical cells forming a hexagonal close-packed lattice. Tissue anisotropy is taken into account by varying interaction forces with the direction of intercellular connection. Several cell-centre interaction potentials for repulsion and attraction are considered, including the Hertz contact model and its neo-Hookean extension, the Johnson-Kendall-Roberts model of adhesive contact, and a wormlike chain model. The model is validated against data from <i>in vitro</i> uni-axial tension tests performed on dissected strips of tunica media. The wormlike chain potential in combination with the neo-Hookean Hertz contact model produces stress-stretch curves which represent the experimental data very well.
Medical subject headings
- Cell Communication
- Cell Movement
- Models, Biological
- Tunica Media