How Does Fat Transition from White to Beige?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28683281.
- Also identified by DOI 10.1016/j.cmet.2017.06.011 and PMC identifier 6088243.
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Abstract
Fischer et al. (2017) recently reported that interleukin-4 (IL-4) does not increase adipose thermogenesis and that activated macrophages do not synthesize catecholamines. These findings are unexpected because IL-4 activation of macrophages has been proposed to have a pivotal role in cold-induced thermogenesis by stimulating macrophage catecholamine production to recruit thermogenic beige or brite fat.
Medical subject headings
- Adipose Tissue, Brown
- Interleukin-4
- Thermogenesis