Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28683284.
- Also identified by DOI 10.1016/j.cmet.2017.05.014 and PMC identifier 5890904.
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Abstract
Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes.
Medical subject headings
- Diabetes Mellitus, Type 2
- Glycogen
- Glycogen Storage Disease
- Insulin-Secreting Cells