10 Years of GWAS Discovery: Biology, Function, and Translation.
review · Level V
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- Record sourced from PubMed, PMID 28686856.
- Also identified by DOI 10.1016/j.ajhg.2017.06.005 and PMC identifier 5501872.
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Abstract
Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.
Medical subject headings
- Genome-Wide Association Study
- Translational Research, Biomedical