Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28695899.
- Also identified by DOI 10.1038/ncomms16035 and PMC identifier 5508227.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. Our study identifies a role for SR-A as an innate PRR in regulating adaptive immune responses.
Medical subject headings
- Adaptive Immunity
- Interferon Regulatory Factors
- Macrophages
- Scavenger Receptors, Class A
- T-Lymphocytes, Helper-Inducer