Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28699891.
- Also identified by DOI 10.7554/eLife.24660 and PMC identifier 5531831.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (<i>Lfng),</i> a key modifier of the Notch receptor, is selectively expressed in NSCs. Further, Lfng in NSCs and Notch ligands Delta1 and Jagged1, expressed by their progeny, together influence NSC recruitment, cell cycle duration, and terminal fate. We propose a new model in which Lfng-mediated Notch signaling enables direct communication between a NSC and its descendants, so that progeny can send feedback signals to the 'mother' cell to modify its cell cycle status. Lfng-mediated Notch signaling appears to be a key factor governing NSC quiescence, division, and fate.
Medical subject headings
- Glycosyltransferases
- Hippocampus
- Neural Stem Cells
- Receptors, Notch
- Signal Transduction