Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28708994.
- Also identified by DOI 10.1016/j.cell.2017.06.047.
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Abstract
Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.
Medical subject headings
- Neoplasms
- RNA