Growth-dependent behavioral difference in bacterial chemotaxis.

Abstract

Cells can adjust to their growth environments and regulate their behavior accordingly. To study how cells accomplish this growth-dependent adjustment from the molecular to the behavioral level, we used bacterial chemotaxis as a model system to explore the behavioral difference for bacteria grown in nutrient-rich and nutrient-poor media. We found that bacteria grown in a nutrient-poor medium exhibit faster chemotaxis adaptation, and this enables them to respond more rapidly to a changing environment and increases their ability to localize to a nutrient concentration peak. We identified the molecular mechanisms behind this behavioral difference through coarse-grained modeling, and demonstrated its physiological consequences by simulating bacterial chemotactic motion in spatiotemporally varying environments and in a static environment with a nutrient concentration peak.