Emerging roles of nuclear phosphatase SCP4 in CKD-associated muscle wasting.
Level V
Where this comes from
- Record sourced from PubMed, PMID 28709594.
- Also identified by DOI 10.1016/j.kint.2017.03.046.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cachexia with wasting of muscle protein is a serious complication of chronic kidney disease (CKD). Muscle protein phosphorylation is a potential therapeutic target. Liu et al. reported that small C-terminal domain phosphatase (SCP) 4 was increased in muscles of patients and mice with CKD. Importantly, knockdown of SCP4 significantly ameliorated muscle wasting in CKD mice. Inhibition of SCP4 may represent a novel therapeutic intervention for muscle wasting in patients with CKD.
Medical subject headings
- Renal Insufficiency, Chronic
- Transcription Factors