Science to Practice: Can MR Imaging Cell Tracking of Macrophage Infiltration Be Used as a Predictive Imaging Biomarker for Transplanted Stem Cell Rejection?
Level V
Where this comes from
- Record sourced from PubMed, PMID 28723288.
- Also identified by DOI 10.1148/radiol.2017170536.
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Abstract
Ferumoxytol-enhanced magnetic resonance (MR) imaging of donor-matched and mismatched stem cell transplants demonstrated decreased signal intensity not only for a xenogeneic mismatch in species but, surprisingly, also for a syngeneic mismatch in sex. MR imaging findings were corroborated with intravital fluorescence microscopy (IVM), where nearly 90% of all ferumoxytol-containing cells were found to be macrophages. Hence, MR imaging cell tracking of infiltrating macrophages may have predictive value in determining whether transplanted stem cell rejection will occur.
Medical subject headings
- Cell Tracking
- Graft Rejection
- Macrophages
- Magnetic Resonance Imaging
- Stem Cell Transplantation