Comment on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport".
editorial · Level V
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- Record sourced from PubMed, PMID 28729484.
- Also identified by DOI 10.1126/science.aan2396 and PMC identifier 5741086.
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Abstract
O'Brien <i>et al</i> (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.
Medical subject headings
- DNA Primase
- Oxidation-Reduction